pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• imparts multiple benefits – improved IONP stability, enhanced drug coating, higher drug uptake in macrophages at reduced toxicity and slower drug release. Keywords: drug-nanoparticle interactions; drug uptake; intra-macrophage; iron oxide nanoparticles; norfloxacin; Introduction Nanoparticles have taken

• have also proven to be beneficial in overcoming multidrug resistance by enabling an increased drug uptake [8]. Similarly, physical combination of stabilized IONPs and anti-tuberculosis drugs improve intracellular drug accumulation through efflux pump inhibition [9] or by enhanced membrane

• concentration. The drug uptake is also greater than the uptake observed through our previous work, where the NOR@IONPs enhance the drug uptake of only 7-fold. Furthermore, the relative viability of NOR, NOR@IONPpH5 and NOR@IONPpH10 for 32 µg/mL drug concentration are found to be 102.1, 107.5 and 30.1

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• that sonoporation is responsible for drug uptake mostly applied higher intensity US [72]. Acoustic radiation force The ARF has been defined as a mechanical force that is generated by the transfer of momentum from the US wave to the medium [60]. The radiation force makes any particles suspended in the

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• of apoptosis, suggesting that the actions of P2 on induction of cell apoptosis could be altered after loading in phytosomes. One reason might be the changed drug uptake pathway. The free drugs were taken up by passive transport, while the phytosomes were taken up through endocytosis [39]. Besides

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• and single-walled CNTs, respectively [26][28]. This elevation in the intracellular drug concentration also contributes to the circumvention of chemoresistance, which is major obstacle of chemotherapy in addition to systemic side effects and can be caused by decreased drug uptake, increased drug efflux